【摘 要】
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In our previous study, we found that the transforming growth factor (TGF)-β1 enhanced the metastatic and invasive potential of gastric cancer cells. Proteomics
【机 构】
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Department of Pathology, Basic School of Medicine, Central South University, Changsha 410013, China
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In our previous study, we found that the transforming growth factor (TGF)-β1 enhanced the metastatic and invasive potential of gastric cancer cells. Proteomics was employed in this study to further illustrate the underlying molecular mechanisms. After two-dimensional electrophoresis, image analysis, spot identification, protein identification and database analysis, three proteins, namely, glutathione-S-transferase-π (GST-π), cofilin and heat shock protein 27 (HSP27), were found to be up-regulated in TGF-β1 treated SGC-7901 cells. The findings were further confirmed by Weste blot analysis. These results suggested that GST-π, cofilin and HSP27 might participate in enhanced invasive potential induced by TGF-β1.
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