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应用免疫组织化学ABC法，对10只雄性自发性高血压大鼠和10只正常大鼠脑底动脉单胺能神经纤维分布进行了观察、在自发性高血压鼠脑底血管的大脑前动脉、大脑中动脉和基底动脉壁上均可见棕褐色的免疫反应阳性纤维，纤维较粗，弯曲，环行走行，密度较高。与正常鼠同一部位脑底动脉壁的阳性纤维密度比较有明显增加。经统计学检验，P＜0．05，表明高血压鼠和正常鼠脑底动脉之间的单胺能神经纤维的密度有明显差异。本文结果提示，高血压鼠脑底动脉各主要分支较正常鼠脑底动脉各主要分支有更高密度的单胺能神经纤维分布，这些纤维属于交感神经纤维，说明交感神经可能在高血压鼠的脑血管活动和对高血压的发生和发展具有重要的作用。
Immunohistochemical ABC method was used to observe the distribution of monoamine nerve fibers in the brain of 10 male spontaneously hypertensive rats and 10 normal rats. In the cerebral anterior cerebral artery of spontaneous hypertensive rats, The middle cerebral artery and basilar artery wall are visible tan immune-positive fibers, thick fibers, curved, walking around the line, the higher the density. Compared with the same part of normal rat brain artery wall positive fiber density increased significantly. The statistical test, P <0.05, indicating that there was a significant difference in the density of monoaminergic nerve fibers between hypertensive rats and normal rat cerebral arteries. The results suggest that the main branches of the cerebral artery in hypertensive rats than the normal rat cerebral artery main branches of the higher density of monoamine nerve fibers distribution of these fibers are sympathetic nerve fibers that sympathetic nerve may be hypertensive rats Cerebrovascular activity and has an important role in the occurrence and development of hypertension.