论文部分内容阅读
目的 对血管内皮生长因子基因3'非翻译区936C/T多态性糖尿病视网膜病变(DR)的关联性进行Meta分析.方法 以DR病变组和2型糖尿病对照组基因型分布的比值比(OR)为统计量,应用STATA软件对各研究结果进行一致性检验和数据合并.结果 相关文献未发现显著发表偏倚.分别以等位基因(T/C)、纯合子(TT/CC)、杂合子(CT/CC)、显性模型(TT+ CT/CC)、隐性模型(TT/CT+ CC)对纳入的全部6项研究2439例2型糖尿病患者进行合并统计,所有模型分析均不支持该多态性位点与DR相关.结论 本次meta分析结果不支持VEGF基因936C/T多态性与DR相关.“,”Objective To study the association between the 936C/T polymorphism (rs3025039) in 3'-untranslated region of vascular endothelial growth factor gene and diabetic retinopathy.Methods Data were collected from the following electronic data bases:PubMed,Embase,CNKI and WANFANG data with the last report up to May 30,2014.Pooled ORs and 95％ CIs were calculated in a random effect model by using the software STATA 12.0.Results A total of 1063 cases and 1376 controls from 6 studies fulfilling the inclusion criteria were included in this meta-analysis.Nosignificant association between VEGF + 936C/T polymorphism and DRwas found in any model:allele (T/C),homozygote(TT/CC),heterozygote (CT/CC),dominant model (TT + CT/CC),recessive model (TT/CT + CC).Conclusion Our meta-analysis did not demonstrate that + 936C/T polymorphism (rs3025039) was likely to be associated with susceptibility to DR.