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选用尿激酶、链激酶对35例急性心肌梗塞(AMI)病人进行溶栓治疗.设年龄、性别、病情相似并予以常规治疗的AMI35例作对照.于治疗前后进行心率变异(HRV)分析、Holter监测、心功能测定.分别对比溶栓血管再通组与非再通组及对照组治疗前后的HRV(时域指标:SDNN、rMSSD、PNN_(50);频域法指标:HF、LF、LF/HF)、心肌缺血(发生次数、程度)及心功能(LVEF、LVVD、A/E,MV流速、Wall Index)变化.结果:溶栓致血管再通20例,血管再通组的SDNN、rMSSD、PNN_(50)、HF较对照组及非再通组明显增大(P<0.05～0、01)、LF/HF比值减少(P<0.05),心功能较早而明显得到改善,心肌缺血次数减少(P<0.01).从而表明:溶栓致血管再通影响于左室重构,减小了左室扩张,改善了自主神经失衡状态,心肌缺血减少,心功能得到较快恢复,改善了AMI病人的近期预后.
Thirty-five patients with acute myocardial infarction (AMI) were treated by thrombolytic therapy with urokinase and streptokinase, and 35 patients with AMI who were similar in age and sex and were treated routinely were enrolled as control. HRV analysis was performed before and after treatment. Holter (HRT), time domain index (SDNN, rMSSD, PNN_ (50)), frequency domain method index (HF), LF, LF / HF), myocardial ischemia (number of occurrence, degree) and cardiac function (LVEF, LVVD, A / E, MV flow rate, Wall Index) were analyzed.Results: 20 cases of recanalization caused by thrombolysis and SDNN , RMSSD, PNN_ (50) and HF increased significantly (P <0.05-0.01), LF / HF ratio decreased (P <0.05), and heart function improved significantly earlier than those in control group and non-recanalization group The number of myocardial ischemia decreased (P <0.01), indicating that thrombolysis induced by recanalization of left ventricular remodeling, reduced left ventricular dilatation, improved autonomic imbalance, decreased myocardial ischemia, cardiac function were more Quick recovery, improved the short-term prognosis of AMI patients.