The reason for the failure to forecast the Wenchuan M_S8.0 earthquake is under study, based on the systematically collection of the seismicity anomalies and their analysis results from annual earthquake tendency forecasts between the 2001 Western Kunlun Mountains Pass M_S8.1 earthquake and the 2008 Wenchuan M_S8.0 earthquake. The results show that the earthquake tendency estimation of Chinese Mainland is for strong earthquakes to occur in the active stage, and that there is still potential for the occurrence of a M_S8.0 large earthquake in Chinese Mainland after the 2001 Western Kunlun Mountains Pass earthquake. However the phenomena that many large earthquakes occurred around Chinese Mainland, and the 6-year long quietude of M_S7.0 earthquake and an obvious quietude of M_S5.0 and M_S6.0 earthquakes during 2002～2007 led to the distinctly lower forecast estimation of earthquake tendency in Chinese Mainland after 2006. The middle part in the north-south seismic belt has been designated a seismic risk area of strong earthquake in recent years, but, the estimation of the risk degree in Southwestern China is insufficient after the Ning’er M_S6.4 earthquake in Yunnan in 2007. There are no records of earthquakes with M_S≥7.0 in the Longmenshan fault, which is one of reasons that this fault was not considered a seismic risk area of strong earthquakes in recent years. The reason for the failure to forecast the Wenchuan M_S8.0 earthquake is under study, based on the systematically collected of the seismicity anomalies and their analysis results from annual earthquake pre- forecasts between the 2001 Western Kunlun Mountains Pass M_S8.1 earthquake and the 2008 Wenchuan M_S8.0 earthquake. The results show that the earthquake tendency estimation of Chinese mainland is for strong earthquakes to occur in the active stage, and that there is still potential for the occurrence of a M_S8.0 large earthquake in Chinese Mainland after the 2001 Western Kunlun Mountains Pass earthquake. However the phenomena that many large earthquakes occurred around Chinese Mainland, and the 6-year long quietude of M_S7.0 earthquake and an obvious quietude of M_S5.0 and M_S6.0 earthquakes during 2002 ~ 2007 led to the distinctly lower forecast estimation of earthquake tendency in Chinese Mainland after 2006. The middle part in the north-south seismic belt has been designated a seismic risk area of ​​strong earthquake in recent years, but, the estimation of the risk degree in Southwestern China is insufficient after the Ning’er M_S6.4 earthquake in Yunnan in 2007. There are no records of earthquakes with M_S ≥7.0 in the Longmenshan fault, which is one of reason that this fault was not considered a seismic risk area of ​​strong earthquakes in recent years.