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目的 :考察氨苄西林与输液配伍的稳定性。方法 :采用0 .9%氯化钠注射液、5 %葡萄糖注射液和 10 %葡萄糖注射液各 5 0 0ml加入 6 .0～ 8.0 g氨苄西林盐注射液配伍 ,测定其在不同溶液、不同时间的含量 ,并进一步求出水解动力学参数t0 .9(有效期 )。结果 :氨苄西林注射液在 0 .9%氯化钠注射液或 5 %葡萄糖注射液中较稳定 ,而在 10 %葡萄糖注射液中不稳定。结论 :氨苄西林注射液与 5 %葡萄糖注射液配伍使用时 ,其使用时间不能超过 3.7h,与 10 %葡萄糖注射液配伍使用时必须在 2h内用完 ,否则超过了药品的有效时间[1] 。建议临床用 0 .9%氯化钠注射液与氨苄西林配伍 ,宜在 6h内滴注完毕
Objective: To investigate the stability of ampicillin compatibility with infusion. Methods: 0 .9% sodium chloride injection, 5% glucose injection and 10% glucose injection of 500 ml were added 6. 0 ~ 8.0 g ampicillin salt compatibility, measured in different solutions at different times Content, and further find the hydrolysis kinetic parameters t0 .9 (Validity). Results: Ampicillin injection was more stable in 0.9% sodium chloride injection or 5% glucose injection and unstable in 10% glucose injection. Conclusion: When ampicillin injection and 5% glucose injection are used in combination, their use time can not exceed 3.7 hours. When used with 10% glucose injection, they must be used within 2 hours, otherwise the effective time of the drug is exceeded [1] . Proposed clinical 0.9% sodium chloride injection and ampicillin compatibility should be completed within 6h infusion