动脉粥样硬化作为一种炎症性疾病,研究表明感染因子与动脉粥样硬化的发生与发展有关。Toll样受体是天然免疫系统识别病原微生物的主要受体．在天然免疫反应中具有重要的作用,近年来研究认为Toll样受体之一Toll样受体4与动脉粥样硬化的发生发展密切相关．其可能成为动脉粥样硬化防治的标靶．本文主要对Toll样受体4在动脉粥样硬化的发生发展中的作用作一综述． Atherosclerosis as an inflammatory disease, studies have shown that infection factors and the occurrence and development of atherosclerosis. Toll-like receptors are the primary receptors for the innate immune system to recognize pathogenic microorganisms. Plays an important role in the innate immune response. In recent years, studies suggest that Toll-like receptor 4, one of Toll-like receptors, is closely related to the development of atherosclerosis. It may become the target of prevention and treatment of atherosclerosis. This review focuses on the role of Toll-like receptor 4 in the development of atherosclerosis.