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本文对砷形态分析方法进行了评述。提出了人尿中 As( )、As( )、一甲基砷( MMA)和二甲基砷 ( DMA)的快速、灵敏的形态分析方法。方法基于在 1 5cm长、3μm粒径的 HPL C柱上快速分离不同形态的砷后以灵敏的氢化物发生 /原子荧光检测。常见砷的四种形态的分析只须 4min即可完成 ,检出限在μg/L级。标准样品尿中砷的形态分析结果和标准值吻合很好。本法已应用于摄取砷糖前、后所采集的尿样中砷的形态分析研究。砷糖普遍存在于海藻、牡蛎、贻贝和蚌等海产品中。食用这些含有胂糖的食品后 ,尿液中的 DMA显著增加。环境和职业砷暴露的生物标志物 ( Biomarker)常基于尿液中无机砷及其代谢产物 MMA和 DMA的测定。砷糖的摄入影响这类生物标志物的可靠性 ,应引起高度重视
This article reviews the arsenic speciation analysis method. A rapid and sensitive morphological analysis method of As (), As (), monomethyl arsenic (MMA) and dimethyl arsenic (DMA) in human urine was proposed. The method is based on the rapid hydride generation / atomic fluorescence detection of rapidly separated forms of arsenic on HPL C columns of 15 cm in length and 3 μm in diameter. The common four forms of arsenic analysis can be completed within 4min, the detection limit in μg / L level. Urine in standard samples of arsenic morphology analysis results and the standard value is very good. This method has been applied to the analysis of arsenic speciation in urine collected before and after ingestion of arsenic sugars. Arsenic is common in marine products such as seaweed, oysters, mussels and mussels. After consuming these arsine containing foods, the DMA in urine increased significantly. Environmental and occupational exposure to arsenic (Biomarker) is often based on the determination of inorganic arsenic in urine and its metabolites MMA and DMA. Arsenic sugars affect the reliability of such biomarkers should be highly valued