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目的探讨亚临床甲状腺功能异常时甲状腺功能与血清抵抗素、同型半胱氨酸水平的相关性。方法选择2013年7月-2014年7月初诊为亚临床甲状腺疾病的患者70例,其中亚临床甲亢组32例,亚临床甲减组38例,另选取同一时期健康体检者72例作为对照组。分别测定FT3、FT4、TSH、VB12、FA及血清抵抗素(Resistin)、同型半胱氨酸(Hcy)。研究3组人群亚临床甲状腺功能异常时血清抵抗素及血清同型半胱氨酸的变化。结果亚临床甲亢组与对照组相比Resistin升高,差异有统计学意义(P<0.05),Hcy明显降低(P<0.01),VB12、FA与对照组比较差异无统计学意义(P>0.05)。亚临床甲减组与对照组相比,Resistin及FA下降,差异有统计学意义(P<0.05);而Hcy明显升高(P<0.01)。亚临床甲亢组、亚临床甲减组TSH与Resistin呈负相关,r值分别为-0.516(P<0.01)、-0.411(P<0.05),与Hcy成正相关,r值分别为0.495(P<0.01)、0.441(P<0.01)。结论抵抗素和Hcy的变化可能对判断亚临床甲状腺功能异常的诊断疗效及疾病的发展、治疗有辅助作用。
Objective To investigate the correlation between thyroid function and serum resistin and homocysteine in subclinical thyroid dysfunction. Methods Seventy patients with subclinical thyroid disease were diagnosed in our hospital from July 2013 to July 2014, including 32 patients in subclinical hyperthyroidism group and 38 patients in subclinical hypothyroidism group. Another 72 healthy subjects were selected as control group . The levels of FT3, FT4, TSH, VB12, FA, Resistin, and homocysteine (Hcy) were measured. To study the changes of serum resistin and serum homocysteine in subclinical thyroid dysfunction in three groups. Results The level of Resistin in subclinical hyperthyroidism group was significantly higher than that in control group (P <0.05), and Hcy was significantly lower (P <0.01). There was no significant difference between VB12 and FA in control group ). Compared with control group, Resistin and FA decreased in subclinical hypothyroidism group (P <0.05), while Hcy increased (P <0.01). In subclinical hyperthyroidism group and subclinical hypothyroidism group, TSH was negatively correlated with Resistin, r values were -0.516 (P <0.01), -0.411 (P <0.05), and positively correlated with Hcy, r values were 0.495 (P < 0.01), 0.441 (P <0.01). Conclusion The changes of resistin and Hcy may play an auxiliary role in the diagnosis of subclinical thyroid dysfunction and the development and treatment of the disease.