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目的：观察阿奇霉素在下呼吸道感染患者肺中的浓度。方法：应用微生物法测定肺炎病人血清及支气管灌洗液中阿奇霉素的浓度。结果：患者口服阿奇霉素５００ ｍｇ 后，血清及支气管灌洗液中浓度在４８ ｈ 最高峰值分别是０．３４ μｇ·ｍｌ－ １ 和２ ．２７μｇ·ｍｌ－ １ ，９６ ｈ 时支气管灌洗液浓度和血清浓度分别为０ ．０７ μｇ·ｍｌ－１ 和１ ．３４ μｇ·ｍｌ－１ 。提示肺中浓度明显高于血清浓度。结论：阿奇霉素有较高的组织渗透性。
Objective: To observe the concentration of azithromycin in the lungs of patients with lower respiratory tract infection. Methods: The concentration of azithromycin in serum and bronchial lavage fluid of patients with pneumonia was determined by the method of microbe. Results: The highest peak concentrations of serum and bronchoalveolar lavage fluid at 48 h after oral azithromycin 500 mg were 0.34 μg · ml-1 and 2, respectively. The concentration of bronchoalveolar lavage fluid and serum concentration at 27 μg · ml-1 and 96 h were 0 and 0 respectively. 07 μg · ml-1 and 1. 34 μg · ml-1. Tip lung concentration was significantly higher than serum concentration. Conclusion: Azithromycin has higher tissue permeability.