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目的:观察丹红注射液对高血压合并慢性心力衰竭患者内皮功能、心功能及勃起功能的影响。方法:62例高血压合并慢性心衰患者(心功能为Ⅱ～Ⅲ级)随机分为丹红注射液组和丹参注射液组,在常规西药治疗的基础上分别加用丹红注射液和丹参注射液,2周后比较2组患者血管内皮功能、心功能相关指标以及勃起功能的变化。结果:丹红注射液组治疗后心功能改善,勃起功能好转,内皮功能相关指标一氧化氮(NO)水平及血管性假性血友病因子(vWF)水平明显低于用药前,且均明显优于丹参注射液组。结论:丹红注射液具有改善高血压合并慢性心衰患者血管内皮功能、心功能及勃起功能的作用。
Objective: To observe the effects of Danhong Injection on endothelial function, cardiac function and erectile function in patients with hypertension and chronic heart failure. Methods: Sixty-two hypertensive patients with chronic heart failure (cardiac function grade Ⅱ ~ Ⅲ) were randomly divided into Danhong injection group and Salvia miltiorrhiza injection group. On the basis of conventional western medicine, Danhong injection and Salvia miltiorrhiza After 2 weeks, the vascular endothelial function, cardiac function-related indexes and erectile dysfunction in two groups were compared. Results: After treated with Danhong injection, heart function improved and erectile function improved. The levels of nitric oxide (NO) and von Willebrand factor (vWF), a marker of endothelial function, were significantly lower than those before treatment Better than Salvia injection group. Conclusion: Danhong injection can improve vascular endothelial function, cardiac function and erectile function in patients with hypertension and chronic heart failure.