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目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者外周血组蛋白去乙酰化酶2(HDAC2)浓度与C反应蛋白(CRP)、降钙素原(PCT)及肺功能的关系。方法选择60例AECOPD患者为研究对象,选择年龄、性别相近的40名健康体检者为对照组。测定患者治疗后0、3、7和10 d的HDAC2、CRP、PCT浓度并进行肺功能、血气分析。结果 AECOPD患者在治疗后0、3、7和10 d,外周血CRP、PCT水平均逐渐下降,而HDAC2浓度逐渐升高(P<0.05)。以上4个时间点检测的HDAC2值,与对应时间点检测的CRP、PCT浓度均呈负相关(r_(CRP)=-0.316、-0.435、-0.498和-0.547,r_(PCT)=-0.332、-0.414、-0.481和-0.523,P<0.01)。AECOPD患者HDAC2浓度与同期肺功能呈正相关(r_(FEV1)=0.594,r_(FEV1/预计值%)=0.561,P<0.01)。结论HDAC2可能是AECOPD患者炎症反应的负调控因子,且与患者气流阻塞程度相关。
Objective To investigate the relationship between HDAC2 concentration and C-reactive protein (CRP), procalcitonin (PCT) and pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Sixty AECOPD patients were selected as the research object. Forty healthy subjects with similar age and sex were selected as the control group. The concentrations of HDAC2, CRP and PCT at 0, 3, 7 and 10 days after treatment were determined and lung function and blood gas analysis were performed. Results At 0, 3, 7 and 10 days after treatment, the levels of CRP and PCT in peripheral blood of patients with AECOPD gradually decreased, while the concentrations of HDAC2 gradually increased (P <0.05). The values of HDAC2 in the above four time points were negatively correlated with the concentrations of CRP and PCT detected at corresponding time points (r CRP -0.316, -0.435, -0.498 and -0.547, r PCT = -0.332, -0.414, -0.481 and -0.523, P <0.01). HDAC2 concentrations in AECOPD patients were positively correlated with pulmonary function at the same period (r FEV1 = 0.594, r FEV1 / predicted% = 0.561, P <0.01). Conclusion HDAC2 may be a negative regulator of inflammatory response in patients with AECOPD and is related to the degree of airflow obstruction in patients.