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目的测定高原地区老年人血浆同型半胱氨酸(Homocysteine Hcy)水平,了解血浆Hcy与高原地区老年人心血管危险因素及慢性高原病(CMS)的关系。方法采取随机抽样的方法,对青海省海晏县(平均海拔≥3000m)281例60岁以上者血浆Hcy水平进行了检测分析。结果①高原地区老年人平均血浆Hcy浓度为(17.53±4.00)μmol/L,血浆Hcy水平在年龄、民族、性别之间无明显差异;②对照组42例血浆Hcy水平为(15.30±3.70)μmol/L,高血压组、糖尿病组、超重组血浆Hcy浓度分别为(18.04±3.33)μmol/L、(17.97±3.83)μmol/L和(17.52±4.03)μmol/L,均明显高于对照组(P<0.05);③CMS组血浆Hcy浓度为(19.77±4.90)μmol/L,明显高于对照组(P<0.05)。结论①高原地区老年人血浆Hcy水平在年龄、民族、性别间无明显差异性;②高原地区有心血管危险因素的老年人及CMS患者血浆Hcy水平均增高,提示血浆Hcy水平增高影响着高原地区老年人心血管疾病和CMS的发生发展。
Objective To determine the level of plasma homocysteine (Homocysteine Hcy) in elderly patients in high altitude area and to investigate the relationship between plasma Hcy and cardiovascular risk factors and chronic mountain sickness (CMS) in the elderly at high altitude. Methods A random sampling method was used to detect and analyze the plasma Hcy levels in 281 cases of over 60 years old in Haiyan County of Qinghai Province (mean elevation≥3000m). Results ① The mean Hcy concentration in the elderly in the plateau was (17.53 ± 4.00) μmol / L, while there was no significant difference in age, ethnicity and gender between the two groups. ② The Hcy level in the control group was (15.30 ± 3.70) μmol (18.04 ± 3.33) μmol / L, (17.97 ± 3.83) μmol / L and (17.52 ± 4.03) μmol / L, respectively) in hypertension group, diabetes mellitus group and overweight group were significantly higher than those in control group (P <0.05). ③ The plasma Hcy concentration in CMS group was (19.77 ± 4.90) μmol / L, which was significantly higher than that in control group (P <0.05). Conclusion ① There was no significant difference in age, ethnicity and gender between plasma and plasma Hcy levels in the elderly in the plateau area. (2) Plasma Hcy levels were increased in the elderly and CMS patients with cardiovascular risk factors in the plateau area, suggesting that plasma Hcy level had an impact on the elderly Human cardiovascular disease and CMS development.