论文部分内容阅读
文中报道了小剂量７．５％ＮａＣｌ／６％右旋糖酐－７０（ＨＳＤ）对模拟高原创伤失血性休克大鼠血气及肺组织损伤的影响。在大型低压舱内经股骨骨折，股动脉放血，５ｍｉｎ内使大鼠平均动脉压（ＭＡＰ）降至６．００±０．６７ｋＰａ，维持此血压水平１ｈ后，从股静脉分别输入４ｍｌ／ｋｇ的生理盐水（ＮＳ）、７．５％Ｎａｃｌ（ＨＳ）或ＨＳＤ，观察５ｈ。结果显示ＨＳＤ能明显减轻休克大鼠ＰＯ２、ｐＨ、ＨＣＯ下降的程度；ＨＳＤ治疗后５ｈ肺匀浆丙二醛（ＭＤＡ）、肺含水量低于ＮＳ及ＨＳ组，肺组织损害程度较ＮＳ及ＨＳ组轻。本研究表明ＨＳＤ对高原创伤失血性休克的早期救治有较高的实用价值。
The paper reports the effect of low dose 7.5% NaCl / 6% dextran-70 (HSD) on blood gas and lung tissue injury in mock traumatic hemorrhagic shock rats. In a large low-pressure cabin by the femoral fracture, femoral artery bleeding, within 5min rat mean arterial pressure (MAP) dropped to 6.00 ± 0.67kPa, maintain this blood pressure level 1h, were fed from the femoral vein 4ml / kg of physiology Saline (NS), 7.5% Nacl (HS) or HSD for 5h. The results showed that HSD significantly reduced the level of PO2, pH and HCO in shock rats. 5h after HSD, the lung homogenate malondialdehyde (MDA) and lung water content were lower than those in NS and HS groups. Light group. This study shows that HSD has a high practical value in the early treatment of hemorrhagic shock in altitude sickness.