myc基因家族(c-myc,N-myc,L-myc,c-myb)的扩增或过度表达与ras基因的点突变是肺癌的主要癌基因异常。c-myc基因的扩增或过度表达在人体多种肿瘤中出现,并与病人的不良预后有关。N-myc扩增和过度表达多出现在具有神经内分泌特性的肿瘤组织中,如神经母细胞瘤,小细胞肺癌等。N-myc Amplification or overexpression of the myc gene family (c-myc, N-myc, L-myc, c-myb) and point mutations of the ras gene are major oncogene abnormalities in lung cancer. Amplification or overexpression of the c-myc gene occurs in a variety of human tumors and is associated with a poor patient prognosis. N-myc amplification and overexpression mostly occur in tumor tissues with neuroendocrine characteristics, such as neuroblastoma, small cell lung cancer, and the like. N-myc