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目的分析奥沙利铂+替吉奥化疗联合滋阴健脾祛瘀汤对晚期胃癌患者疗效、生活质量及免疫学指标的影响。方法选择我院在2014年1月~2017年1月收治的晚期胃癌患者44例,采用随机综合序贯法将患者分为对照组22例和观察组22例。两组均予以奥沙利铂+替吉奥化疗治疗,观察组在此基础上添加中药滋阴健脾祛瘀汤。比较两组患者的治疗有效率、生活质量评分、免疫学指标。结果观察组的治疗有效率高于对照组(P<0.05);观察组的生活质量简易量表(QOL-BREF量表)中生理因素和社会关系评分优于对照组(P<0.05);治疗后,观察组的CD4~+、CD3~+免疫功能指标优于对照组,差异有统计学意义(P<0.05)。结论在胃癌晚期的治疗中应用奥沙利铂+替吉奥化疗联合滋阴健脾祛瘀汤,可改善患者的生活质量和免疫功能,提高治疗效果,减少毒副作用,值得临床推广。
Objective To analyze the effect of oxaliplatin plus tegafur chemotherapy combined with yin yin and spleen qi decoction on the efficacy, quality of life and immunological parameters of patients with advanced gastric cancer. Methods Forty-four patients with advanced gastric cancer who were treated in our hospital from January 2014 to January 2017 were selected and randomly divided into a control group and 22 observation groups. Both groups were treated with oxaliplatin and schizotron chemotherapy, and the observation group added Chinese medicine Ziyin Jianpiyutang on the basis of this. The treatment efficiency, quality of life score, and immunological indicators were compared between the two groups of patients. Results The treatment efficiency of the observation group was higher than that of the control group (P<0.05). The physiological factors and social relationship scores of the observation group’s QOL-BREF scale were better than the control group (P<0.05); After the observation, the immune function of CD4+ and CD3+ in the observation group was better than that in the control group, and the difference was statistically significant (P<0.05). Conclusion The combination of oxaliplatin and schizonitrile chemotherapy and Ziyin Jianpi Decoction in the treatment of advanced gastric cancer can improve the patient’s quality of life and immune function, improve the treatment effect, reduce the toxic and side effects, and is worthy of clinical promotion.