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目的探讨膜联蛋白Ⅰ(AnnexinⅠ)在胃癌组织中的表达及临床意义。方法收集胃癌患者手术标本88例(研究组),以相应癌旁组织作为正常对照(对照组),运用免疫组化检测胃癌及癌旁组织中AnnexinⅠ的表达,并分析其与胃癌临床病理参数之间的关系。结果研究组AnnexinⅠ阳性表达率18.18%显著低于对照组86.36%,差异有统计学意义(P<0.01);AnnexinⅠ的表达随着胃癌临床分期演进和浸润深度的增加而下调,各组比较差异均有统计学意义(P<0.05);AnnexinⅠ的表达与胃癌的分化程度相关,分化越差其表达越低,各组比较差异均有统计学意义(P<0.05);且有淋巴结转移的AnnexinⅠ的表达显著低于无淋巴结转移组,差异有统计学意义(P<0.05)。结论 AnnexinⅠ的表达下调可能是胃黏膜恶性转变以及胃癌发生浸润转移的重要生物学标志。
Objective To investigate the expression of annexin Ⅰ in gastric carcinoma and its clinical significance. Methods 88 cases of gastric cancer patients (study group) were collected, the corresponding paracancerous tissues were taken as normal control group (control group), immunohistochemistry was used to detect the expression of Annexin Ⅰ in gastric cancer tissues and paracancerous tissues, and its correlation with clinicopathological parameters Relationship between. Results The positive rate of Annexin Ⅰ in study group was significantly lower than that in control group (18.18% vs 86.36%, P <0.01). The expression of Annexin Ⅰ was down-regulated with the increase of clinical stage and depth of invasion. (P <0.05). The expression of Annexin I was correlated with the degree of differentiation of gastric cancer. The lower the expression was, the lower the expression was and the difference was statistically significant (P <0.05). Annexin I with lymph node metastasis The expression was significantly lower than without lymph node metastasis, the difference was statistically significant (P <0.05). Conclusions The down-regulation of Annexin I expression may be an important biomarker of malignant transformation of gastric mucosa and invasion and metastasis of gastric cancer.