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目的观察卡托普利联合美托洛尔治疗慢性心力衰竭(CHF)的疗效。方法 106例CHF患者随机分为治疗组53例和对照组53例,对照组采用强心剂、利尿剂和卡托普利,治疗组在对照组的治疗基础上加用美托洛尔。观察治疗前和治疗6月后左室射血分数(LVEF)、左室舒张末期内径(LVEDD)及临床心功能分级变化。结果治疗前后LVEF、LVEDD及心功能好转情况,联合组均优于对照组,差异均有统计学意义(P<0.05)。结论卡托普利与美托洛尔联合治疗CHF疗效较好,值得临床进一步推广。
Objective To observe the efficacy of captopril combined with metoprolol in the treatment of chronic heart failure (CHF). Methods One hundred and sixty patients with CHF were randomly divided into treatment group (n = 53) and control group (n = 53). The control group was treated with tacrolimus, diuretic and captopril. The treatment group was treated with metoprolol on the basis of the control group. The changes of left ventricular ejection fraction (LVEF), left ventricular end-diastolic diameter (LVEDD) and clinical cardiac function before and 6 months after treatment were observed. Results Before and after treatment, LVEF, LVEDD and heart function improved, the combination group were better than the control group, the difference was statistically significant (P <0.05). Conclusion Captopril and metoprolol combined treatment of CHF better curative effect, it is worth further clinical promotion.