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目的PDT联合TSPA灌注治疗多发性非浸润性膀胱癌的疗效。方法入选患者按3～5mg/kg的剂量将HPD加入5%葡萄糖溶液内作静脉注射,注药后48～72h即可开始PDT。PDT治疗后分为A、B两组:A组18例,待腔内的肿瘤照射完后30min内,膀胱内灌注TSPA90mg。两周后采用TSPA60mg溶解在60ml生理盐水中注入膀胱。每周1次,6周后改为每月1次共10次。B组18例,PDT后只做相应的对症处理。16个月后评定疗效。结果治疗后,A组的有效率为44.4%(8/18),总有效率77.7%(14/18);B组的有效率为33.3%(6/18),总有效率61.1%(11/18)。两组相比,具有统计学意义,P<0.05,A组疗效优于B组。药物不良反应及复发率比较,A组明显优于B组。结论PDT联合TSPA治疗膀胱癌可提高治疗有效率,延缓和减少复发率及种植率,提高患者生存质量。
Objective To evaluate the efficacy of PDT and TSPA in the treatment of multiple non-invasive bladder cancer. Methods Selected patients by 3 ~ 5mg / kg dose of HPD by adding 5% glucose solution for intravenous injection, injection 48 ~ 72h PDT. After PDT treatment, the patients were divided into A and B groups: 18 cases in group A, and TSPA90mg was intravesical instilled within 30 minutes after tumor in the cavity was irradiated. Two weeks later, TSPA 60 mg dissolved in 60 ml saline was injected into the bladder. Once a week, 6 weeks later changed to a total of 10 times a month. B group 18 cases, only after the corresponding symptomatic treatment PDT. After 16 months to assess the efficacy. Results After treatment, the effective rate of group A was 44.4% (8/18), the total effective rate was 77.7% (14/18); the effective rate of group B was 33.3% (6/18), the total effective rate was 61.1% (11 / 18). Compared with the two groups, with statistical significance, P <0.05, A group better than the B group. Drug adverse reactions and recurrence rate, A group was significantly better than the B group. Conclusion PDT combined with TSPA in the treatment of bladder cancer can improve the treatment efficiency, delay and reduce the recurrence rate and implantation rate, improve patient quality of life.