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目的研究补肾复方对围绝经期大鼠卵巢谷胱甘肽过氧化物酶(GSH-Px)活力的影响。方法用Wistar雌性大鼠,根据重量和阴道细胞角化指数分层,中药干预后采用化学比色法测定卵巢GSH-Px的活性。结果与对照组比较,中药补肾复方高剂量组升高明显,差异有统计学意义(P<0.05),中、低剂量组无明显差异(P>0.05);与青年组比较,高剂量组卵巢GSH-Px的活力水平接近青年组,差异无统计学意义(P>0.05),其余各组差异有统计学意义(P<0.05)。结论中药可以通过改善卵巢的酶性保护系统,调节卵巢功能,从而达到延缓卵巢衰老的目的。
Objective To study the effects of Bushen Compound on the activity of glutathione peroxidase (GSH-Px) in perimenopausal rats. Methods The Wistar female rats were stratified by weight and vaginal keratinization index. The activity of GSH-Px in ovary was determined by chemical colorimetry after the intervention of Chinese medicine. Results Compared with the control group, the traditional Chinese medicine Bushen Compound high-dose group increased significantly, the difference was statistically significant (P <0.05), medium and low dose group had no significant difference (P> 0.05); Compared with the young group, high dose ovariectomy group The vitality of GSH-Px was similar to that of the youth group (P> 0.05), but there was no significant difference between the other groups (P <0.05). Conclusion Chinese medicine can improve ovarian enzymatic protection system and regulate ovarian function so as to delay ovarian aging.