目的：探讨ｐ５３、ｃｅｒｂＢ２基因表达与胃癌发生的生物学行为之间的关系。方法：应用免疫组化Ｓｐ法检测１８例早期胃癌、４０例进展期胃癌、１４例不典型增生、２２例肠上皮化生及１６例浅表性胃炎中抑癌基因ｐ５３、原癌基因ｃｅｒｂＢ２的蛋白表达。结果：浅表性胃炎组织中ｐ５３、ｃｅｒｂＢ２无表达；肠上皮化生组织中ｐ５３、ｃｅｒｂＢ２表达率分别为２２７％、１３６％；不典型增生组织中ｐ５３、ｃｅｒｂＢ２表达率分别为６４３％、２８６％；早期胃癌组织中ｐ５３、ｃｅｒｂＢ２表达率分别为３３３％、１１１％；进展期胃癌组织中ｐ５３、ｃｅｒｂＢ２表达率分别为５２５％、５５％；不典型增生和进展期胃癌的ｐ５３表达率均高于肠上皮化生（Ｐ＜００５）；进展期胃癌的ｃｅｒｂＢ２表达率高于早期胃癌和肠上皮化生（Ｐ＜００１）；ｃｅｒｂＢ２在有淋巴结转移胃癌中的表达率（６４３％）高于无淋巴结转移（２０％）（Ｐ＜００１）；中、低分化腺癌的ｐ５３表达率均高于高分化腺癌（Ｐ＜００５）；胃癌组织中ｐ５３、ｃｅｒｂＢ２表达有很强的相关性（Ｐ＜００１）。结论：ｐ５３、ｃｅｒｂＢ２基因协同作用参与? Objective: To investigate the relationship between p53 and cerbB2 gene expression and the biological behavior of gastric cancer. Methods: Immunohistochemical Sp method was used to detect tumor suppressor gene p53 and proto-oncogene c in 18 cases of early gastric cancer, 40 cases of advanced gastric cancer, 14 cases of atypical hyperplasia, 22 cases of intestinal metaplasia and 16 cases of superficial gastritis. erbB 2 protein expression. Results: There was no expression of p53 and cerbB2 in superficial gastritis tissues. The expression rates of p53 and cerbB2 in intestinal metaplasia were 227% and 136%, respectively. The expression rates of p53 and cerbB2 were 643% and 286% respectively. The expression rates of p53 and cerbB2 in early gastric cancer were 333% and 111%, respectively; The expression rates of p53 and cerbB2 were 525% and 55%, respectively. The rate of p53 expression in dysplasia and advanced gastric cancer was higher than that in intestinal metaplasia (P<005); advanced gastric cancer The expression rate of cerbB2 was higher than that of early gastric cancer and intestinal metaplasia (P<001). The expression rate of cerbB2 in gastric cancer with lymph node metastasis (64. 3%) was higher than that without lymph node metastasis ( 20%)(P<001); The rate of p53 expression in moderately and poorly differentiated adenocarcinomas was higher than that in well-differentiated adenocarcinomas (P<005); Tissues p53, cerbB2 expression of a strong correlation (P <001). Conclusion: The p53 and cerbB2 genes are involved in the synergistic effect.