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目的探讨高氧液对病毒性脑炎患儿脑组织保护作用的机制。方法以2004年1～12月武汉市儿童医院收治的40例病毒性脑炎患儿为研究对象,随机分为常规治疗组和高氧液治疗组(常规治疗+高氧液),治疗前后观察临床症状及脑影像学改善情况,并采用放射免疫法监测脑脊液内皮素(ET)和降钙素基因相关肽(CGRP)质量浓度变化。结果与常规组比较,高氧液组临床症状和脑影像学改变的消失时间以及住院时间明显缩短(P<0.05,P<0.01);ET、ET/CGRP比值降低和CGRP升高更为显著(P<0.05,P<0.01)。结论①ET/CGRP比值失衡是导致病毒性脑炎发生、发展的重要因素;②高氧液通过改善脑组织供氧、恢复ET/CGRP动态平衡,从而发挥其保护作用。
Objective To investigate the protective mechanism of hyperoxic liquid on brain tissue in children with viral encephalitis. Methods A total of 40 children with viral encephalitis admitted to Children’s Hospital of Wuhan from January to December in 2004 were randomly divided into routine treatment group and hyperoxia liquid treatment group (conventional treatment + hyperoxic liquid), before and after treatment The clinical symptoms and brain imaging were evaluated. Radioimmunoassay was used to monitor the changes of cerebrospinal fluid endothelin (ET) and calcitonin gene related peptide (CGRP). Results Compared with the conventional group, the disappearance time and length of hospital stay of the hyperoxia group were significantly shorter (P <0.05, P <0.01); the ET, ET / CGRP ratio and the elevated CGRP were more significant P <0.05, P <0.01). Conclusion ① The imbalance of ET / CGRP ratio is an important factor leading to the occurrence and development of viral encephalitis. (2) Hyperoxic fluid can play a protective role by improving the oxygen supply of brain tissue and restoring the dynamic balance of ET / CGRP.