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目的探讨血清降钙素原(PCT)、C-反应蛋白(CRP)在新生儿感染性疾病中的临床意义。方法 2015年1月至2015年6月期间,我院90例新生儿感染性疾病(35例重症感染伴全身症状、55例局部感染但无全身症状),根据细菌培养、血清学检验,将其分为细菌感染组(57例)、非细菌感染组(33例),并比较血清PCT、CRP水平,另选取同期30例非感染性疾病新生儿作为对照组研究对象。结果与对照组相比,重症感染组、局部感染组的血清CRP、PCT、白细胞计数水平明显升高(P<0.05);与局部感染组相比,重症感染组血清CRP、PCT、白细胞计数水平明显升高(P<0.05);与非细菌感染组相比,治疗前细菌感染组血清CRP、PCT浓度均明显升高(P<0.05);与治疗前相比,治疗后细菌感染组血清CRP、PCT浓度明显降低(P<0.05)。结论 CRP、PCT检测有利于新生儿感染性疾病的早期诊断及疗效评估,动态监测感染程度及控制情况。
Objective To investigate the clinical significance of serum procalcitonin (PCT) and C-reactive protein (CRP) in neonatal infectious diseases. Methods From January 2015 to June 2015, 90 cases of neonatal infectious diseases (35 cases of severe infection with systemic symptoms, 55 cases of local infection but no systemic symptoms) in our hospital were studied. According to bacterial culture and serological tests, The patients were divided into bacterial infection group (57 cases) and non-bacterial infection group (33 cases). Serum PCT and CRP levels were also compared. Thirty newborns with noninfectious disease in the same period were selected as control group. Results Compared with the control group, the levels of serum CRP, PCT and WBC in severe infection group and local infection group were significantly increased (P <0.05). Compared with the local infection group, the serum CRP, PCT, leukocyte count (P <0.05). Compared with non-bacterial infection group, serum CRP and PCT concentrations in bacterial infection group before treatment were significantly increased (P <0.05). Compared with before treatment, serum CRP , PCT concentration was significantly lower (P <0.05). Conclusion The detection of CRP and PCT is beneficial to the early diagnosis and therapeutic evaluation of neonatal infectious diseases and the dynamic monitoring of infection and control.