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目的观察阿托伐他汀对治疗冠心病伴高血脂症的临床疗效及安全性。方法将64例冠心病伴高血脂症患者随机分为观察组和对照组各32例。对照组给予阿托伐他汀20mg/d口服,观察组给予阿托伐他汀10mg/d口服,对两组患者的临床疗效、血脂达标率、并发症和不良反应发生率。结果两组TC、LDL-C较治疗前均明显降低(P<0.01),HDL-C较治疗前也有升高(P<0.05)。两组血脂达标率、并发症和不良反应发生率无明显差异(P>0.05)。结论阿托伐他汀10mg1次/d给药剂量治疗轻中度的高血脂症疗效好,相对费用低,值得推广。
Objective To observe the clinical efficacy and safety of atorvastatin in the treatment of coronary heart disease with hyperlipidemia. Methods 64 cases of coronary heart disease with hyperlipidemia were randomly divided into observation group and control group, 32 cases each. Control group was given atorvastatin 20mg / d orally, the observation group was given atorvastatin 10mg / d orally, the clinical efficacy of two groups of patients, blood lipid compliance rate, complications and adverse reactions. Results TC and LDL-C in both groups were significantly lower than those before treatment (P <0.01), HDL-C also increased compared with those before treatment (P <0.05). Two groups of blood lipid compliance rate, the incidence of complications and adverse reactions no significant difference (P> 0.05). Conclusion Atorvastatin 10mg / d dosing for the treatment of mild to moderate hyperlipidemia effect, the relative cost is low, it is worth promoting.