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三唑啉(硫)酮是一类重要的杂环化合物,具有较高的生物活性和产品附加值。本路线以己内酰胺为起始原料,经过硫酸二甲酯的甲基化反应得到中间体(Ⅰ),该中间体与肼基甲酸甲酯或肼基二硫代甲酸甲酯通过环化反应可得到三唑啉(硫)酮并环庚胺类杂环化合物。该化合物结构经过~1HNMR和MS表征。该合成方法具有条件温和、分离纯化简单、各步收率较高的优点,是合成此类杂环的一种好方法,适合工业化生产。
Triazoline (thio) ketone is a class of important heterocyclic compounds, with high biological activity and product added value. This route to caprolactam as the starting material, after dimethyl sulfate methylation to give the intermediate (I), the intermediate and carbazate or hydrazino dithiocarbamate obtained through the cyclization reaction Triazoline (Thio) Ketoheptanoamino Heterocyclic Compounds. The structure of the compound was characterized by ~ 1HNMR and MS. The synthesis method has the advantages of mild conditions, simple separation and purification and high yield of each step, and is a good method for synthesizing such heterocyclic rings and is suitable for industrialized production.