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目的 探讨经组织学证实的 11例乳腺浸润性小叶癌 (ILC)的细胞学穿刺涂片 ,能否进行正确的组织学分类。方法 收集 11例经组织学证实的ILC的细胞学穿刺涂片 ,同时与乳腺浸润性导管癌FNAC进行对比观察。并应用图像分析系统行细胞形态分析。结果 发现ILC在细胞学上具有一定的特点。其细胞体积小 ,核及核仁亦小 ,异型性不明显。涂片中细胞数量较少 ,单个散在的癌细胞较多 ,以小细胞群为多。约半数以上病例表现为单个小细胞呈线样或“列兵样”排列。结论 以上特点反映了的组织学结构。我们认为针吸细胞学对于多数ILC病例可以作出乳腺浸润性小叶癌的分型诊断。
Objective To investigate the histologically confirmed cytological puncture smears of 11 cases of invasive lobular carcinoma of the breast (ILC) and whether they can be correctly classified. Methods 11 cases of histologically confirmed ILC cytology puncture smear were collected and compared with FNAC of invasive ductal carcinoma of the breast. And apply image analysis system for cell morphology analysis. Results It was found that ILC is cytologically characterized. The cell size is small, the nucleus and nucleolus are also small, and the heteromorphism is not obvious. The number of cells in the smear is small, and the number of scattered single cancer cells is more, and the small cell population is more. About half of the cases showed a single small cell line or “pillar-like” arrangement. Conclusion The above features reflect the histological structure. We believe that needle aspiration cytology can be used for the diagnosis of breast infiltrating lobular carcinoma in most cases of ILC.