瘦素是肥胖基因编码的一种蛋白质产物,主要由白色脂肪组织分泌,通过与其受体结合发挥抑制食欲、减少能量摄入、增加能量消耗的生物学作用.近年来大量临床研究显示瘦素与冠心病的发生、发展密切相关,现就瘦素在冠心病发病中的作用机制作一综述。 Leptin is a protein product encoded by obesity gene, which is mainly secreted by white adipose tissue and plays a biological role in inhibiting appetite, reducing energy intake and increasing energy consumption through binding with its receptor .In recent years, a large number of clinical studies have shown that leptin and Coronary heart disease is closely related to the occurrence and development, now on the role of leptin in the pathogenesis of coronary heart disease are reviewed.