卡托普利(Captopril)系一种口服血管紧张素转换酶抑制剂,是广泛用于治疗高血压有效的首选药物。然而,该药有两大缺点:(1)临床使用时需日服3次,摄入总量37.5～75mg才能维持6～8h 的作用时间;(2)当与食物同时服用时,其生物利用度明显下降。研究表明,高 pH 条件是使之发生降解的主要原因。 Captopril, an oral angiotensin-converting enzyme inhibitor, is the drug of choice for effective treatment of hypertension. However, the drug has two major drawbacks: (1) three times daily for clinical use, and 37.5-75 mg for a total duration of 6-8 hours; (2) bioavailability when taken simultaneously with food Degree decreased significantly. Studies have shown that high pH conditions are the main cause of degradation.