论文部分内容阅读
目的研究胸腺素-4(Tβ-4)、胸腺素-10(Tβ-10)、胸腺素-15(Tβ-15)在乳腺癌组织和乳腺增生组织中的表达,分析其临床意义。方法采用免疫组化法检测乳腺癌组织和乳腺增生组织中Tβ-4、Tβ-10和Tβ-15水平,比较乳腺癌患者和乳腺增生患者Tβ-4、Tβ-10和Tβ-15的差异;并分析乳腺癌患者Tβ-4、Tβ-10和Tβ-15表达水平与临床病理学参数的相关性。结果乳腺癌组织中Tβ-4、Tβ-10和Tβ-15表达水平显著高于乳腺增生组织(P<0.05)。雌孕激素受体阳性者和有淋巴结转移者乳腺癌Tβ-4、Tβ-10和Tβ-15阳性表达率分别高于雌孕激素受体阴性者和无淋巴节转移(P<0.05)。结论乳腺癌组织中Tβ-4、Tβ-10和Tβ-15呈高表达性,且其阳性率与肿瘤的病理分型有关,因此这些指标可以作为乳腺癌诊断、转移风险预测和预后评估的生物标志物。
Objective To study the expression of Tβ-4, Tβ-10 and Tβ-15 in breast cancer tissues and breast hyperplasia tissues and to analyze the clinical significance. Methods The levels of Tβ-4, Tβ-10 and Tβ-15 in breast cancer tissues and breast hyperplasia tissues were detected by immunohistochemistry. The differences of Tβ-4, Tβ-10 and Tβ-15 in breast cancer and breast hyperplasia were compared. And analyze the correlation between the expression of Tβ-4, Tβ-10 and Tβ-15 in breast cancer and clinicopathological parameters. Results The expression of Tβ-4, Tβ-10 and Tβ-15 in breast cancer tissues was significantly higher than that in breast hyperplasia tissues (P <0.05). The positive rates of Tβ-4, Tβ-10 and Tβ-15 in estrogen and progesterone receptor positive and lymph node metastasis were higher than that in estrogen and progesterone receptor negative and without lymph node metastasis (P <0.05). Conclusion The expressions of Tβ-4, Tβ-10 and Tβ-15 in breast cancer tissues are highly expressed, and their positive rates are related to the pathological classification of the tumors. Therefore, these markers can be used as biomarkers for breast cancer diagnosis, metastasis risk prediction and prognosis evaluation landmark.