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目的探讨醒脑静注射液治疗急性有机磷农药中毒的临床疗效。方法 84例急性有机磷农药中毒患者随机分为治疗组42例和对照组42例。对照组给予常规治疗,治疗组在常规治疗基础上加用醒脑静注射液静脉滴注,每次20mL,每日1次。观察两组患者的神志清醒时间、胆碱酯酶恢复时间、住院时间、中间综合征发生率、治愈率以及病死率。结果治疗组患者神志清醒时间、ChE恢复时间、住院时间较对照组明显缩短(P<0.01或P<0.05)。治疗组治愈率为88.1%(37/42)高于对照组的69.0%(29/42)(P<0.05)。中间综合征发生率、病死率均低于对照组(P<0.05)。结论在常规治疗的基础上,合用醒脑静治疗急性有机磷农药中毒可以提高临床疗效,降低病死率。
Objective To investigate the clinical effect of Xingnaojing injection on acute organophosphorus pesticide poisoning. Methods Eighty-four patients with acute organophosphorus pesticide poisoning were randomly divided into treatment group (n = 42) and control group (n = 42). Control group given conventional treatment, the treatment group on the basis of conventional treatment plus Xingnaojing injection intravenous drip, each 20mL, 1 day. The conscious time, recovery time of cholinesterase, length of hospital stay, incidence of intermediate syndrome, cure rate and mortality of the two groups were observed. Results The conscious time, ChE recovery time and hospital stay in treatment group were significantly shorter than those in control group (P <0.01 or P <0.05). The cure rate in the treatment group was 88.1% (37/42), which was higher than that in the control group (69.0%, 29/42) (P <0.05). Intermediate syndrome incidence and mortality were lower than the control group (P <0.05). Conclusion On the basis of routine treatment, combined with Xingnaojing acute organophosphate pesticide poisoning can improve clinical efficacy and reduce mortality.