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目的：研究血管内皮生长因子（VascularendothelialgrowthfactorVEGF）抗体的抗骨肉瘤血管生成作用。方法：应用鸡胚尿囊膜（ChickembryoChorioallantoicmembrane，CAM）模型观察VEGF抗体对骨肉瘤血管生成及肿瘤生长的影响。结果：VEGF抗体组血管数目在给予抗体后第2、4、6、8天均显著低于PBS对照组（P＜0．05或P＜0．01），光镜下瘤细胞减少，新生血管腔减少。结论：VEGF抗体对骨肉瘤治疗具有良好的应用前景。
Objective: To study the antiangiogenic effect of Vascular endothelial growth factor (VEGF) antibody on osteosarcoma. Methods: The effect of VEGF antibody on the angiogenesis and tumor growth of osteosarcoma was observed with chick embryo chorioallantoic membrane (CAM) model. Results: The number of vascular endothelial cells in the VEGF antibody group was significantly lower than that in the PBS control group (P <0.05 or P <0.01) on days 2, 4, 6, and 8 after administration of the antibody. The numbers of neovascularization Cavity reduction. Conclusion: VEGF antibody has a good prospect for the treatment of osteosarcoma.