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目的探讨大剂量甲钴胺片联合卡马西平治疗特发性三叉神经痛患者的临床疗效。方法收集2013年1月至2015年1月阜新市中心医院神经内科收治的特发性三叉神经痛患者资料100例,按随机数字表法将其分为对照组和观察组,各50例。对照组患者使用卡马西平,观察组患者在对照组基础上加用大剂量甲钴胺片。比较两组患者的临床疗效、视觉模拟量表(VAS)评分以及不良反应发生率。结果观察组患者治疗有效率为92.0%,明显高于对照组的70.0%,差异有统计学意义(P<0.05);治疗后,观察组患者的VAS评分、不良反应发生率均明显低于对照组,差异均有统计学意义(均P<0.05)。结论大剂量甲钴胺片联合卡马西平治疗特发性三叉神经痛患者的疗效明显,可有效缓解疼痛,降低不良反应发生率,安全可靠。
Objective To investigate the clinical efficacy of high-dose mecobalamin combined with carbamazepine in patients with idiopathic trigeminal neuralgia. Methods A total of 100 patients with idiopathic trigeminal neuralgia admitted to Fuxin Central Hospital from January 2013 to January 2015 were enrolled in this study. They were divided into control group and observation group according to random number table. Control group patients with carbamazepine, observation group patients in the control group based on the use of large doses of mecobalamin tablets. The clinical efficacy, visual analog scale (VAS) score and the incidence of adverse reactions were compared between the two groups. Results The effective rate of observation group was 92.0%, which was significantly higher than that of control group (70.0%) (P <0.05). After treatment, VAS score and adverse reaction rate in observation group were significantly lower than those in control group Group, the differences were statistically significant (all P <0.05). Conclusion High-dose mecobalamin tablets combined with carbamazepine in the treatment of idiopathic trigeminal neuralgia patients with significant effect, which can effectively relieve pain, reduce the incidence of adverse reactions, safe and reliable.