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目的:观察丹芪祛瘀止痛颗粒对于胃溃疡(GU)的防治作用。方法:雄性SD大鼠分为5组:CDB高、中、低剂量组(1,0.5,0.25g·kg~(-1)),阳性对照组(雷尼替丁,0.027g·kg~(-1))和空白组(纯水,10mL·kg~(-1))。复制应激性胃溃疡和醋酸灼伤胃溃疡模型,分别观察药物对于溃疡发生的防治作用,同时测定动物血清中表皮生长因子(EGF)和转化生长因子(TGF-α)水平。结果:丹芪祛瘀止痛颗粒能够降低溃疡指数,减少溃疡面积,并明显降低胃液总酸度(P<0.01或P<0.05)。丹芪祛瘀止痛颗粒高、中剂量可以显著提高胃两种溃疡模型动物血清中EGF和TGF-α水平(P<0.01或P<0.05),但是对胃蛋白酶活性无明显影响(P>0.05)。结论:丹芪祛瘀止痛颗粒可以通过抑制胃酸分泌和增强保护因子来起到抗实验性胃溃疡的作用。
Objective: To observe the preventive and therapeutic effects of Danqi Quyu Zhitong Granule on gastric ulcer (GU). Methods: Male Sprague-Dawley rats were randomly divided into 5 groups: high, medium and low doses of CDB (1, 0.5, 0.25g · kg -1), positive control group (ranitidine, 0.027g · kg ~ -1)) and blank group (pure water, 10 mL · kg -1). Coping of gastric ulcer and acetic acid burn gastric ulcer model were used to observe the preventive and therapeutic effects of the drug on the occurrence of ulcer. The levels of epidermal growth factor (EGF) and transforming growth factor (TGF-α) in serum were also determined. Results: Danqi Quyu Zhitong Granule can reduce the ulcer index, reduce the ulcer area, and significantly reduce the total acidity of gastric juice (P <0.01 or P <0.05). The high and medium dose of Danqi Quyu Zhitong Granule could significantly increase the levels of EGF and TGF-α in serum of two ulcer models (P <0.01 or P <0.05), but had no significant effect on pepsin activity (P> 0.05) . Conclusion: Danqi Quyu Zhitong Granule can prevent gastric ulcer by inhibiting gastric acid secretion and enhancing protective factor.