[Objective] To discuss the effects of HERBA CISTANCHES on the ability of resistance exercise-induced fatigue of rats and on the free radical in the brain tissue,so as to provide theoretical basis for the application of its resistance exercise-induced fatigue.[Method]Raised for four days,the rats were randomly subdivided into four groups(n=15) like static gavaged water group(C group),static gavaged HERBA CISTANCHES group(M group),movement gavaged water group(T group) and movement HERBA CISTANCHES group(TM group).Twenty-eight days later,the body weight of rats,swimming time when they were exhausted and the content of MDA,SOD,GSH-Px in rats’ brain mitochondria in each group were determined.[Result] The rats in M group and C group had no significant differences in body weight,while those in T group were less than those in C group(P<0.01).The body weight of rats in TM group were less than those in M group(P<0.05).Rats in TM group was longer in exhaustive swimming time than T group(P<0.01).Rats in TM group was lower in MDA content(P<0.01) and was higher in SOD and GSH-Px activity compared with those in T group(P<0.01).[Conclusion] HERBA CISTANCHES is provided with effect of lessening the lipid peroxidation in brain tissue of rats and oxidative damage of mitochondrial by exercise-induced fatigue. [Objective] To discuss the effects of HERBA CISTANCHES on the ability of resistance exercise-induced fatigue of rats and on the free radical in the brain tissue, so as to provide theoretical basis for the application of its resistance exercise-induced fatigue. [Method ] Raised for four days, the rats were randomly subdivided into four groups (n = 15) like static gavaged water group (C group), static gavaged HERBA CISTANCHES group (M group), movement gavaged water group (T group) and movement HERBA CISTANCHES group (TM group). Twenty-eight days later, the body weight of rats, swimming time when they were exhausted and the content of MDA, SOD, GSH-Px in rats’ brain mitochondria in each group were determined. [Result] The rats in M ​​group and C group had no significant differences in body weight, while those in T group were less than those in C group (P <0.01). Body weight of rats in TM group were less than those in M ​​group ( P <0.05) .Rats in TM group was longer in exhaustive swimming time than T group (P <0.01) .R ats in TM group was lower in MDA content (P <0.01) and was higher in SOD and GSH-Px activity compared with those in T group (P <0.01). [Conclusion] HERBA CISTANCHES is provided with effect of lessening the lipid peroxidation in brain tissue of rats and oxidative damage of mitochondrial by exercise-induced fatigue.