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为了解出生时体重、婴儿期体重和儿童期呼吸道感染与成人的肺功能和慢性阻塞性呼吸道疾病的死亡是否有关,作者随访调查了1911～1930年间出生于英格兰哈德福夏郡的5718人,其中825人出生于1920年～1930年,并一直生活在那里。由卫生巡查员调查记录他们出生时的体重、1岁时体重以及儿童期疾病。测定平均第一秒用力呼气量(FEV_1)和用力肺活量(FVC),以及调查他们的呼吸道症状和死于慢性阻塞性呼吸道疾病的人数。结果 55人死于慢性阻塞性呼吸道疾病。死亡率随着出生时体重和1岁时体重的增加而降低。经校正身高和年龄之后,59岁～70岁者随出生时体重每增加1磅(450克)其平均 FEV_1增加0.06L(95%可信区间在0.02～0.09),且
To understand whether birth weight, infancy weight, and childhood respiratory infections are associated with adult lung function and chronic obstructive airway disease deaths, the authors followed up with 5718 people born in Hadfordshire, England from 1911 to 1930, Of these, 825 were born between 1920 and 1930 and have lived there ever since. Surveys by health inspectors record their birth weight, weight at 1 year, and childhood illness. Mean first-second forced expiratory volume (FEV_1) and forced vital capacity (FVC) were measured, and their respiratory symptoms and death from chronic obstructive respiratory disease were measured. 55 people died of chronic obstructive respiratory disease. Mortality decreases with birth weight and weight gain at 1 year of age. After adjusting for height and age, the average FEV 1 increased by 0.06 L (95% CI, 0.02 to 0.09) for each 59-to-70-year-old weight gain of 1 pound (450 g)