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目的:评估高尿酸血症(Hyperuricemia,HUA)与动脉硬化(Arteriosclerosis,AS)的关系。方法:收集841例通过检测心-踝血管指数(Cardio-ankle vascular index,CAVI)诊断为动脉硬化的人群作为研究组,采取成套配对1:1病例对照方案,收集非动脉硬化人群(CAVI<9.0),841例为对照组,分析两组人群中血尿酸、血脂、空腹血糖、血压、体质指数及腰围的差异性。校正混杂因素后比较两组人群中血尿酸的差异,研究高尿酸血症与动脉硬化的相关性。结果:研究组与对照组间人群的腰围、收缩压、空腹血糖、血清总胆固醇、三酰甘油、高密度脂蛋白胆固醇及血尿酸存在统计学差异(P=0.000),校正混杂因素后,血尿酸是动脉硬化的危险因素(OR=1.003 Cl95%1.002-1.004 P=0.000)。高尿酸血症在两组间的优势比为1.657(P=0.000 Cl95%1.311-2.101)。结论:除血脂、血糖、血压及腰围等因素外,高尿酸血症同动脉硬化关系密切。
Objective: To evaluate the relationship between Hyperuricemia (HUA) and Arteriosclerosis (AS). Methods: A total of 841 patients with atherosclerosis diagnosed by Cardio-ankle vascular index (CAVI) were enrolled in this study. Patients were enrolled in the study. Patients in non-arteriosclerosis group (CAVI <9.0) ), 841 cases as control group. The differences of serum uric acid, blood lipid, fasting blood glucose, blood pressure, body mass index and waist circumference were analyzed in two groups. After adjusting for confounding factors, the difference of serum uric acid between the two groups was compared to study the correlation between hyperuricemia and arteriosclerosis. Results: The waist circumference, systolic blood pressure, fasting blood glucose, serum total cholesterol, triglyceride, high density lipoprotein cholesterol and serum uric acid in the study group and control group were significantly different (P = 0.000). After the confounding factors were corrected, Uric acid is a risk factor for atherosclerosis (OR = 1.003 Cl95% 1.002-1.004 P = 0.000). The odds ratio for hyperuricemia between the two groups was 1.657 (P = 0.000 Cl95% 1.311-2.101). Conclusion: In addition to blood lipids, blood glucose, blood pressure and waist circumference and other factors, hyperuricemia and atherosclerosis are closely related.