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大鼠背根节 (dorsal root ganglion,DRG)神经元在慢性压迫损伤后可自发产生大量不规则的阵发放电。为探讨此类放电序列的动力学机制 ,我们以单纤维引导的方法记录了受损神经元阵发放电的动作电位间期 (interspike interval,ISI)序列 ,并计算得到放电的事件间期 (interevent interval,IEI)序列。然后 ,运用一种从时间序列中识别非稳定周期轨道 (unstable periodic orbits,UPOs)的新方法对阵发放电 IEI序列进行分析。从得到的 1 0例数据中无一例外地检测到了具有高度统计显著性的非稳定周期 1轨道。在此基础上 ,进一步对阵发放电的非稳定周期轨道分级进行了初步研究 ,检测到了显著的周期 2与周期 3轨道。结果表明 :受损 DRG神经元的不规则阵发放电节律具有显著地确定性动力学机制。
In rats, dorsal root ganglion (DRG) neurons spontaneously produce a large number of irregular spontaneous discharges after chronic compression injury. In order to investigate the kinetic mechanism of such discharge sequences, we recorded the interspike interval (ISI) sequences of damaged neurons by monofilament-guided methods and calculated the interevent interval, IEI) sequence. Then, a new method of identifying unstable IEs (IEs) from time series was used to analyze the IEI sequences. From the obtained 10 cases of data, the highly statistically significant non-stable period 1 orbit was detected without exception. On the basis of this, a preliminary study was conducted on the classification of unsteady periodic orbits that sent out electricity. Significant periods 2 and 3 were detected. The results show that there is a significant deterministic kinetic mechanism of irregularly-distributed firing rhythms in impaired DRG neurons.