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目的:研究扇贝糖蛋白及扇贝多糖对S180小鼠的抑瘤作用。方法:给小鼠接种S180腹水瘤,用不同剂量扇贝糖蛋白及扇贝多糖治疗,观察瘤重及脾脏重量。结果:40 mg·kg-1扇贝糖蛋白对S180小鼠抑瘤率为47．29％,20 mg·kg-1扇贝多糖抑瘤率为46．97％;扇贝多糖还可明显增加小鼠脾脏重量。结论:扇贝糖蛋白及扇贝多糖抑瘤效果显著,扇贝多糖还具增强免疫功能作用。
Objective: To study the inhibitory effect of scallop glycoprotein and scallop polysaccharide on S180 mice. METHODS: Mice were inoculated with S180 ascitic fluid tumors, treated with different doses of scallop glycoprotein and scallop polysaccharide, and the tumor weight and spleen weight were observed. Results: The inhibitory rate of 40 mg·kg-1 scallop glycoprotein to S180 mice was 47.29%, and the inhibitory rate of 20 mg·kg-1 scallop polysaccharide was 46.97%. Scallop polysaccharide also significantly increased the mouse spleen weight. Conclusion: Scallop glycoprotein and scallop polysaccharide have significant anti-tumor effect. Scallop polysaccharide can also enhance immune function.