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目的评价阿奇霉素的两种不同给药方案在治疗小儿肺炎支原体肺炎中的成本及效果。方法将217例小儿肺炎支原体肺炎患者随机分为常规治疗组(98例)、序贯治疗组(119例),其中常规治疗组采用注射用乳糖酸阿奇霉素按7d用药方案连续静脉滴注,序贯治疗组采用注射用乳糖酸阿奇霉素静脉注射4d,后改用阿奇霉素颗粒剂口服序贯给药治疗3d,并对两种方案进行成本及效果分析。结果两组在有效率及不良反应发生率方面无显著差异性(P>0.05),但常规治疗组的治疗成本却明显高于序贯治疗组(P<0.001)。结论对小儿肺炎支原体肺炎,采用阿奇霉素静脉给药治疗,患者病情稳定后及时改用口服序贯给药治疗不但安全、有效,而且费用明显减少。
Objective To evaluate the cost and effectiveness of two different dosage regimens of azithromycin in the treatment of children with Mycoplasma pneumoniae pneumonia. Methods A total of 217 children with Mycoplasma pneumoniae pneumonia were randomly divided into routine treatment group (n = 98) and sequential treatment group (n = 119). The routine treatment group received intravenous infusion of azithromycin lactate for 7 days, In the treatment group, intravenous injection of azithromycin lactobionate was used for 4 days, then azithromycin granules were administered orally for sequential treatment for 3d, and the cost and effect of the two schemes were analyzed. Results There was no significant difference between the two groups in the incidence of adverse reactions (P> 0.05), but the treatment cost was significantly higher in the conventional treatment group than in the sequential treatment group (P <0.001). Conclusion Mycoplasma pneumoniae pneumonia in children, the use of azithromycin intravenous treatment, patients with stable condition and timely switch to oral sequential administration is not only safe and effective, but the cost was significantly reduced.