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测定了肺结节病患者支气管肺泡灌洗液中Ｔ淋巴细胞亚群，结果显示结节病患者的ＣＤ４／ＣＤ８比值（７．５±４．３）显著高于对照组（２．１±０．７）（Ｐ＜０００１）。肺泡灌洗液中ＣＤ４／ＣＤ８比值对肺结节病诊断的敏感性和特异性分别为８６％和１００％。研究结果证实测定肺泡灌洗液中ＣＤ４／ＣＤ８比值对于结节病的鉴别诊断亦有重要意义。连续测定ＣＤ４水平有助于临床评价和监测病变活动情况。
The T lymphocyte subsets in bronchoalveolar lavage fluid of patients with pulmonary sarcoidosis were determined. The results showed that the CD4 / CD8 ratio (7.5 ± 4.3) in patients with sarcoidosis was significantly higher than that in the control group (2.1 ± 0 .7) (P <0001). The sensitivity and specificity of CD4 / CD8 ratios in BALF for the diagnosis of pulmonary sarcoidosis were 86% and 100%, respectively. The results confirmed that the determination of the ratio of CD4 / CD8 in BALF is also important for the differential diagnosis of sarcoidosis. Continuous determination of CD4 levels is helpful for clinical evaluation and monitoring of disease activity.