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在甲醇溶液中,还原希夫碱HL[N-(2-吡啶甲基)-L-丝氨酸]与CuCl_2·2H_2O以摩尔比1∶1反应,得到1个新的中性单核铜配合物[CuLCl(H_2O)](Ⅰ).通过X射线单晶衍射、元素分析、红外光谱、电喷雾质谱和粉末X射线衍射分析等对其进行了表征.晶体结构分析表明,在该配合物中还原希夫碱以三齿双螯合环配位到中心铜离子,同时氯离子和溶剂水分子也参与配位,形成1个具有四方锥构型的五配位铜(Ⅱ)配合物,该配合物通过分子间弱相互作用连接成二维超分子结构.生物活性测试结果表明,配合物Ⅰ能有效抑制蛋白酪氨酸磷酸酶1B(PTP1B)和T细胞蛋白酪氨酸磷酸酶(TCPTP),IC_(50)值分别为0.32和0.45μmol/L.
Reduction of Schiff base HL [N- (2-picolyl) -L-serine] with CuCl 2 · 2H 2 O in a molar ratio of 1: 1 in methanol gave 1 new neutral mononuclear copper complex [ CuCl (H 2 O)] (Ⅰ) .It was characterized by X-ray single crystal diffraction, elemental analysis, infrared spectroscopy, electrospray ionization mass spectrometry and powder X-ray diffraction analysis.The crystal structure analysis showed that in the complex Fufarin coordinates to the central copper ion with a tridentate bis-chelate ring, while the chloride and solvent water molecules are also involved in the coordination to form a pentacoordinated copper (II) complex with a tetragonal cone configuration Through the weak intermolecular interaction into two-dimensional supramolecular structure.The biological activity test results show that the complex Ⅰ can effectively inhibit protein tyrosine phosphatase 1B (PTP1B) and T cell protein tyrosine phosphatase (TCPTP), IC_ (50) values were 0.32 and 0.45 μmol / L, respectively.