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目的观察正常婴儿听性脑干反应(ABR)潜伏期及阈值正常值范围,为早期干预治疗提供依据。方法应用美国ICS CHARTR诱发电位仪对40例(80耳)听力正常的婴儿和20例听力正常成人进行ABR检测,根据年龄分为A组(3~4月龄)、B组(5~6月龄)、对照组。建立不同月龄婴儿ABR正常值范围,讨论性别、耳别、月龄对测试结果的影响及阈值测定的临床应用。结果80dB nHL短声刺激下,A组A easeBR波Ⅰ、Ⅲ、Ⅴ潜伏期的正常值范围分别是:(1.52±0.19)m s、(4.20±0.20)m s、(6.34±0.26)m s;B组ABR波Ⅰ、Ⅲ、Ⅴ潜伏期的正常值范围分别是:(1.50±0.09)m s、(4.05±0.16)m s、(6.16±0.25)m s;对照组ABR波Ⅰ、Ⅲ、Ⅴ潜伏期的正常值范围分别是:(1.43±0.10)m s、(3.63±0.15)m s、(5.50±0.16)m s。随着月龄的增长,婴儿各波的潜伏期(PL)和波间期(IPL)均缩短;但6月龄时仍未达成人水平。A、B两组各波的潜伏期及波间期与对照组比较差异均有统计学意义(P<0.05);A组与B组比较Ⅲ、Ⅴ波潜伏期及Ⅰ-Ⅲ、Ⅰ-Ⅴ波间期差异具有统计学意义(P<0.05)。女婴潜伏期和波间期短于男婴(A组内Ⅰ-Ⅲ波间期除外),A组内男女间Ⅴ波潜伏期差异具有统计学意义(P<0.05);B组内男女Ⅲ、Ⅴ波潜伏期及Ⅰ-Ⅴ波间期差异有统计学意义(P<0.05);各组内左右耳差异无统计学意义(P>0.05)。各月龄组及正常成人ABR反应阈差异无统计学意义。结论建立不同月龄婴儿ABR潜伏期及阈值正常值标准,为听损伤的早期诊断和随访监测提供可靠依据。
Objective To observe the latency and normal range of normal infant brainstem response (ABR), and provide basis for early intervention. Methods ABR was detected in 40 (80 ears) normal hearing infants and 20 normal adults with ICS CHARTR evoked potentials. The patients were divided into three groups according to their ages: group A (3-4 months), group B (5-6 months) Age), control group. To establish the normal range of ABR in infants of different ages, to discuss the influence of sex, ear and age on the test results and the clinical application of threshold measurement. Results The normal range of latency of Ⅰ, Ⅲ and Ⅴ of A easeBR in group A were (1.52 ± 0.19) ms and (4.20 ± 0.20) ms respectively, (6.34 ± 0.26) ms and 80% The normal ranges of latency of wave Ⅰ, Ⅲ and Ⅴ were (1.50 ± 0.09) ms, (4.05 ± 0.16) ms and (6.16 ± 0.25) ms, respectively. The normal range of latency of ABR wave Ⅰ, Ⅲ and Ⅴ in control group were Is: (1.43 ± 0.10) ms, (3.63 ± 0.15) ms, (5.50 ± 0.16) ms. With the increase of age, the infant’s wave latency (PL) and wave interval (IPL) were shortened; but not reached the adult level at 6 months of age. The latency and wave interval of each wave in A and B groups were statistically different from that in control group (P <0.05). The latency of Ⅲ and Ⅴ wave and the wave interval of Ⅰ-Ⅲ and Ⅰ-Ⅴ in A group and B group The difference was statistically significant (P <0.05). The latent period and the wave interval of female infants were shorter than that of the male infants (except Ⅰ-Ⅲ wave interval in group A), and there was significant difference in the latency of wave Ⅴ between men and women in group A (P <0.05) There were significant differences in wave latency and I-V wave interval (P <0.05). There was no significant difference between the left and right ears in each group (P> 0.05). There was no significant difference in ABR threshold between each age group and normal adults. Conclusion Establishing the standard of ABR latency and threshold value for infants of different ages provides a reliable basis for the early diagnosis and follow-up monitoring of hearing impairment.