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过去由于对代谢性骨质病的病理生理认识不足,所以对骨质病的药物治疗未曾重视。随着对钙代谢的生理性调节及影响骨吸收和形成的因素的逐步认识,现已有一些新药用于治疗骨质病。甲状旁腺激素(PTH) 甲状旁腺浸膏(PTE)目前主要用于诊断,可用来鉴别低钙血症或高钙血症。特发性甲状旁腺功能低下或手术后低钙血症患者用PTE后,尿中磷酸盐和环-磷酸腺苷(c-AMP)排量增加,而大部分假性甲状旁腺功能低下病人的靶器官则无反应,而且在注射PTE后尿中c-AMP及磷酸盐的排量不增加。但有的病人尿中c-AMP可能增加,而肾排出磷酸盐无变化。高钙血症患者输注PTE、钙或EDTA钠
In the past because of the lack of understanding of the pathophysiology of metabolic osteopathies, so the drug treatment of osteoporosis has not been valued. With the gradual understanding of the physiological regulation of calcium metabolism and the factors affecting bone resorption and formation, some new drugs are now available for the treatment of osteoporosis. Parathyroid hormone (PTH) Parathyroid extract (PTE) is currently predominantly used for diagnosis and can be used to identify hypocalcemia or hypercalcaemia. After PTE in patients with idiopathic hypoparathyroidism or postoperative hypocalcemia, urinary phosphate and c-AMP levels increased, whereas most patients with pseudo-hypoparathyroidism Of the target organs are non-responsive, and in the urine after injection of c-AMP and phosphate did not increase the displacement. However, some patients urinary c-AMP may increase, while the renal phosphate excretion unchanged. Patients with hypercalcemia are infused with PTE, calcium or sodium EDTA