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目的:总结膜细胞骨架连接蛋白Ezrin与肿瘤的侵袭转移之间关系的研究现状,探讨其在肿瘤转移中的重要作用及复杂机制。方法:应用pubMed及CNKI期刊全文数据库检索系统,以“Ezrin,埃兹蛋白,肿瘤”等为关键词,检索1999-2009年的相关文献,共检到文献486条。纳入标准:1)Ezrin促进肿瘤转移的机制。2)Ezrin抑制肿瘤转移的机制。3)Ezrin在不同肿瘤中的异常表达与预后。根据纳入标准,精选分析35篇文献。结果:Ezrin可以通过多种复杂的机制,在不同条件下发挥促进或是抑制肿瘤转移的作用。但是Ezrin在不同肿瘤中上调或下调的具体机制尚不清楚。它与其他肿瘤侵袭转移相关因子间的关系及信号转导机制也需进一步完善。结论:虽然Ezrin在肿瘤侵袭转移中的作用具有两面性,但其具体的调控机制和作用条件需要更加深入地研究和综合分析。
OBJECTIVE: To summarize the current status of the study on the relationship between Ezrin and the invasion and metastasis of tumor, and to explore its important role in tumor metastasis and its complicated mechanism. Methods: PubMed and CNKI journals full text database retrieval system was used to search the relevant literature from 1999 to 2009 with the keywords of “Ezrin, Ezrin, Tumor” and so on. 486 articles were found. Inclusion criteria: 1) Ezrin mechanism to promote tumor metastasis. 2) Ezrin mechanism of tumor metastasis. 3) abnormal expression and prognosis of Ezrin in different tumors. Based on the inclusion criteria, 35 articles were selected for analysis. Results: Ezrin can promote or inhibit tumor metastasis under different conditions through a variety of complex mechanisms. However, the exact mechanism by which Ezrin is up-regulated or down-regulated in different tumors is unclear. It and other tumor invasion and metastasis-related factors and the relationship between signal transduction mechanisms need to be further improved. Conclusion: Although the role of Ezrin in tumor invasion and metastasis has two sides, but its specific regulatory mechanisms and conditions need to be more in-depth study and comprehensive analysis.