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作者对30例胃癌患者血清硒含量及其中18例胃癌组织样本硒含量的研究发现:胃癌患者的血清硒含量远远低于健康人(P<0.001),而癌组织样本的硒含量却明显高于同源正常胃壁组织(P<0.01),关于胃癌组织中硒含量测定目前报告甚少。作者认为:(1)人群中血清硒水平与胃癌的发生呈负相关。这同目前的大多数报道相同。(2)胃癌患者癌组织中硒含量高于正常胃壁表明,硒有肿瘤的趋向性和浓集现象,这给补硒抗癌研究提供了乐观的前景,对进一步研究补硒时机、补硒利弊、补硒途径及补硒量都有帮助。(3)胃癌病人硒的分布特点可能会更加导致血清硒的降低。(4)作者提醒大家注意:少数胃癌患者血清晒含量接近正常值,所以一定要注意假阴性结果的出现,甚至发生误诊。
The authors studied the serum selenium content in 30 patients with gastric cancer and the selenium content in 18 gastric cancer tissue samples found that the serum selenium content in patients with gastric cancer was much lower than that in healthy people (P<0.001), but the selenium content in cancer tissue samples was significantly higher. In the homogenous normal gastric tissue (P<0.01), there is currently very little report on the determination of selenium in gastric cancer. The authors believe that: (1) There is a negative correlation between serum selenium levels and the occurrence of gastric cancer in the population. This is the same as most of the current reports. (2) The selenium content in the cancer tissues of gastric cancer patients is higher than that in the normal stomach wall, indicating that selenium has the trend of tropism and concentration of tumors. This provides optimistic prospects for research on selenium and anticancer, and further studies the selenium timing and the advantages and disadvantages of selenium supplementation. Selenium supplementation and selenium supplementation all help. (3) The distribution of selenium in gastric cancer patients may lead to a decrease in serum selenium. (4) The author reminds everyone that the serum content of a few patients with gastric cancer is close to normal, so we must pay attention to the occurrence of false negative results, and even misdiagnosis.