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目的:探讨B型利钠肽(BNP)判断脓毒症患者病情及预后的价值。方法:测定并比较2013年3月至2014年6月我科收治的感染性休克组(n=55)和严重脓毒症组(n=70)于入住ICU 0 h、24 h、48 h、72 h的血浆BNP水平;并根据住院28 d死亡情况分为死亡组(n=31)和存活组(n=94),并比较两组血浆BNP水平差异。结果:感染性休克组各时点的血浆BNP水平均显著高于严重脓毒症组(P均<0.01);死亡组血浆BNP水平在入ICU的各时点均显著高于存活组(P均<0.01);感染性休克组的血浆BNP水平与急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分和序贯器官功能衰竭评分(SOFA)均有较好相关性。结论:血浆BNP对脓毒症患者病情严重程度及预后具有判断价值。
Objective: To investigate the value of B-type natriuretic peptide (BNP) in judging the condition and prognosis of sepsis patients. Methods: The septic shock group (n = 55) and severe sepsis group (n = 70) admitted to ICU from March 2013 to June 2014 were measured and compared for 0 h, 24 h, 48 h, (N = 31) and survivors (n = 94) according to the 28-day hospital stay, and to compare the plasma BNP level between the two groups. Results: Plasma BNP levels in septic shock group were significantly higher than those in severe sepsis group (all P <0.01). BNP levels in death group were significantly higher than those in survival group <0.01). The level of plasma BNP in septic shock group was correlated well with acute physiology and chronic health status score system Ⅱ (APACHE Ⅱ) and sequential organ failure score (SOFA). Conclusion: Plasma BNP is of value in determining the severity and prognosis of septic patients.