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目的研究微生态制剂双歧三联活菌胶囊辅助治疗溃疡性结肠炎的疗效及可能机制。方法将2004年11月至2006年6月南昌大学第一附属医院消化科就诊的溃疡性结肠炎初治患者82例随机分成观察组及对照组,每组41例。对照组采用常规治疗,观察组在常规治疗的基础上加用双歧三联活菌胶囊。比较两组治疗前及治疗2个月后患者的临床症状评分、结肠黏膜炎症评分、结肠黏膜IgA的表达及外周血T淋巴细胞亚群、免疫球蛋白和补体C3、C4的差异。结果治疗2个月后两组临床症状评分、结肠黏膜炎症评分及结肠黏膜IgA均较治疗前有明显改善(P<0.01),且观察组临床症状、结肠黏膜炎症改善程度优于对照组(P<0.01),结肠黏膜IgA免疫反应阳性颗粒数高于对照组(P<0.05);外周血T淋巴细胞亚群、免疫球蛋白和补体C3、C4与治疗前比较差异均无显著性意义(P>0.05);观察组CD4+/CD8+比值较对照组显著升高(P<0.05)。结论双歧三联活菌胶囊可辅助治疗溃疡性结肠炎,其机制可能与影响结肠黏膜IgA及T淋巴细胞亚群构成有关。
Objective To study the efficacy and possible mechanism of the probiotics probiotic Bifidus triplex capsule in the treatment of ulcerative colitis. Methods From November 2004 to June 2006, 82 patients with newly diagnosed ulcerative colitis attending the Department of Gastroenterology, the First Affiliated Hospital of Nanchang University were randomly divided into observation group and control group, with 41 cases in each group. The control group was treated by routine treatment. The observation group was treated with bifid triple viable capsule on the basis of routine treatment. The clinical symptom score, colonic mucosal inflammation score, colonic mucosa IgA expression, peripheral blood T lymphocyte subsets, immunoglobulin and complement C3, C4 were compared between two groups before treatment and 2 months after treatment. Results After 2 months of treatment, the scores of clinical symptoms, colonic mucosal inflammation score and IgA of colonic mucosa were significantly improved (P <0.01), and the improvement of clinical symptoms and colonic mucosal inflammation in the observation group was better than that of the control group (P <0.01). The number of IgA immunoreactive granules in colonic mucosa was significantly higher than that in control group (P <0.05). There was no significant difference in T lymphocyte subsets, immunoglobulin, complement C3 and C4 in peripheral blood between the two groups > 0.05). The ratio of CD4 + / CD8 + in the observation group was significantly higher than that in the control group (P <0.05). Conclusion Bifid triple viable capsule can be used to assist the treatment of ulcerative colitis, the mechanism may be related to the formation of colonic mucosa IgA and T lymphocyte subsets.