Mitofi lin是一种线粒体内膜蛋白,与多种线粒体蛋白相互作用,共同参与线粒体内膜嵴形态的维持、线粒体内蛋白质的转运过程等。干扰mitofi lin的表达不仅引起线粒体结构的异常,而且明显抑制了线粒体功能的正常发挥。最近的研究表明,在多种疾病中mitofi lin都异常表达,从而导致线粒体结构的完整性和功能的障碍,促进了疾病的发生发展。 Mitofi lin is a mitochondrial inner membrane protein that interacts with a variety of mitochondrial proteins and participates in the maintenance of mitochondrial ridges, the transport of proteins within mitochondria, and the like. Interfering mitofi lin expression not only caused the abnormality of mitochondrial structure, but also obviously inhibited the normal function of mitochondria. Recent studies have shown that mitofi lin is abnormally expressed in a variety of diseases, resulting in the structural integrity and dysfunction of mitochondria, contributing to the development of the disease.