论文部分内容阅读
儿童皮肌炎(juvenile dermatomyositis,JDM)指18岁以内发病的皮肌炎,其为罕见皮肤疾病之一。在英美国家,JDM的发病率每年约为(1.9~4.1)/1 000 000[1-2]。在遗传学上,儿童皮肌炎与成人皮肌炎存在共同之处。Shinjo等[3]对56例JDM与成人皮肌炎患者进行了对照研究,结果显示,MHCⅠ类分子的过度表达与这2组皮肌炎间均具有相关性,且与JDM间的相关性更为显著。有研究报道,研究发现JDM与成人皮肌炎的发生均与HLA 8.1单倍型
Juvenile dermatomyositis (JDM) refers to the onset of dermatomyositis within 18 years of age, which is one of the rare skin diseases. In Anglo-American countries, the incidence of JDM is approximately 1.9 to 4.1 per 1,000,000 per year [1-2]. Genetics, children with dermatomyositis and adult dermatomyositis have common. Shinjo et al [3] 56 cases of patients with adult dermatomyositis and JDM control study showed that MHC class I molecules overexpression and these two groups were associated with dermatomyositis, and the correlation between the more JDM For the obvious. Some studies have reported that the discovery of both JDM and adult dermatomyositis is associated with the HLA 8.1 haplotype