一、前言众所周知,青年患者能够耐受良好的洋地黄投予量,对于老年患者则可发生洋地黄毒性反应。究其原因,老化心肌对正常洋地黄血药浓度敏感性增加;老年的糖甙类动力学的转变可导致较高的洋地黄心肌浓度;或者由于患者体重的不同,使用药剂量估计错误。二、老化与洋地黄敏感性人类老化进程中甲状腺功能、肾脏排泄 First, the preamble As we all know, young patients can tolerate good digitalis dosage, digitalis toxicity can occur in elderly patients. The reason for this is that the aging myocardium is more susceptible to normal digitalis concentration; the change in glycosidic kinetics in older people can lead to higher concentrations of digitalis in myocardium; or, because of differences in body weight, the dose estimates are incorrect. Second, aging and digitalis Sensitivity of human aging process of thyroid function, renal excretion